Biosynthesis of steroidal saponins

Ginger is one of the best pain killers in the world having analgesic properties like the popular ibuprofen, only better. It contains a quartet, gingerols, paradols, shogaols, and zingerone which are active ingredients to reduce pain. Ginger reduces pain-causing prostaglandin levels in the body. A study by researchers found that when people who were suffering from muscular pain were given ginger, they all experienced improvement. The recommended dosage of ginger is between 500 and 1,000 milligrams per day. Drink ginger tea or place shavings in your foods. Either way will get you relief from that recurring pain.

STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.

Pantethine is safer and works the same. It is the active ingredient in Vitamin B5. If you have -any questions, feel free to ask me and I'll respond in this thread.
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Jul 16 2007, 12:44 PM

guys,
I wish I had seen the info on pantethine before starting b5 powder 10 days ago. I have had moderate acne for 30 years... had 4 rounds of accutane. Currently on minocycline, tazorac, % benzoyl peroxide. This minimized my acne to 2-3 small lesions at any time.
So far, the b5 is affecting my skin AS WELL AS accutane. My oil slick of a face is almost at normal sebum levels already. My nose isn't shiny after all day at work. I'm excited, because if I can back off the dosage after 3 months, it could be a maintenance drug!!! No more oily skin and zits!

I think I'll maintain the b5 and watch for posts from people who have switched over to the pantethine.

BTW: I am an inorganic chemist and medical researcher. This stuff is not without side effects (diarrhea-common, hair loss-rare). From what I've read, you need to take a multi-b vitamin while megadosing b5. Since it's water soluble (not fat soluble) the excess will be excreted from your body. Compared to accutane (stores in the liver) risks are minor.
Good luck!!!!
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Aug 13 2007, 01:25 AM

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Biosynthesis of steroidal saponins

biosynthesis of steroidal saponins

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

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