Usually, steroid is taking orally or infusing intravenously. Glomerulonephritis, renal tubular- interstitial disease and rejection after kidney transplantation all can be treated by corticosteroid. Among all those disease, primary glomerulonephritis, for example, minimal change disease reacts well to the medication. Focal Segmental Glomerulosclerosis respond badly to steroid. 25% of specific membrane nephropathy people could get a remission all by themselves, while 25% of them may progress to ESRD. As for IgA Nephropathy , steroid isn’t recommended in cases of simple microscopic hematuria. For patients with III or IV of lupus nephritis, glucocorticoid becomes the basic medication.