The synthesis starts with the condensation of 3-acetylacetanilide   ( 1 ) with N , N -dimethylformamide dimethyl acetal ( DMFDMA )  to give the eneamide ( 2 ). The anilide nitrogen is then alkylated by means of sodium hydride and ethyl iodide to give 3 . The first step in the condensation with 3-amino-4-cyanopyrazole can be visualized as involving an addition-elimination reaction sequence on the eneamide function to give a transient intermediate such as 5 . Cyclization then leads to formation of the fused pyrimidine ring to afford zaleplon ( 6 ).
Yes, I agree acid reflux is painful but please don’t blame the oil specifically. I use doterra (and other oils) in healing protocols for my clients but I’m always very adamant for them to understand these, although natural are to be though of as medicine. I’m replying just so others know to take it seriously to avoid conditions like your own. DEFINITELY take with food – did you take in a capsule? I hope you didn’t just put the oil in a glass of water as that wouldn’t be good. I only recommend taking internally with a full meal and enough liquid AND not to lay down directly after. Keep in mind, there are risks with everything – people can harm themselves by drinking too much water or taking too many vitamins. The key is to use these things judiciously and only take advice from those that really know what they’re doing!