At 18, fresh from high school, Marina, Ignacio, Adam and Mimi, school mates bonded by fate, shared a dream about adult life, a dream of fame, success, perfect skin and that one endless, true love that, surely, was waiting just around the corner for each one of them. But 30's arrived, and none of the sweet promises of youth was fulfilled. Alone, failed and frustrated, all four are forced to stop and look around to try to understand where it all went wrong, and find an emergency fix for their lives, before it's too late, and happiness escapes through their fingers forever. Secondary Effects is the bitter coming of age comedy that follows their steps in the search for lost dreams, lost hair and good sex, at least, if true love turns out to be a mirage. Written by Anonymous
In the UK, Peter Bradshaw of The Guardian awarded the film a maximum five stars, calling it "a gripping psychological thriller about big pharma and mental health that cruelly leaves you craving one last fix". He praised the lead performance from Rooney Mara as "compelling" who "lays down the law with her presence. She demonstrates a potent Hitchcockian combination: an ability to be scared and scary at the same time, and Soderbergh's film manages to introduce its effects in some insidious, almost intravenous way".  The . Club ' s Scott Tobias called Mara "superb as the glue that binds this fractured psychological puzzle," and commended Soderbergh's sophisticated direction: " Side Effects screws around in its own thriller architecture, toying with feints of structure and clever bits of misdirection, and otherwise playing the audience like a fiddle. At this point in his career, Soderbergh pulls it off with the unpracticed ease of a maestro."  Robbie Collin of The Daily Telegraph awarded Side Effects a maximum five stars and also acknowledged its debt to earlier psychological thrillers. He wrote: "There's a lot of Alfred Hitchcock in what follows, but even more Henri-Georges Clouzot , with whose classic spine-tingler Les Diaboliques (1954) Soderbergh's film shares a poisonous tang".  Peter Travers of Rolling Stone praised the film's performances, the script and direction, writing "Soderbergh delivers ticking-bomb suspense laced with psychological acuity about a world where mood-altering meds are as disturbingly prevalent as social media".