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NSAIDS have antipyretic activity and can be used to treat fever. [75] [76] Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation. [75] [77] Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus . [75] [76] PGE2 signals to the hypothalamus to increase the body's thermal set point. [76] [78] Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen). [77] [79] Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.

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6. Sironi M, Milanese C, Vecchi A, Polenzani L, Guglielmotti A, Coletta I, et al. „Benzydamine inhibits the release of tumor necrosis factor-a and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells.“ Intl Clin Lab Res. 1997; 27 (2): 118-22
7. Sironi M, Massimiliano L, Transidico P, Pinza M, Sozzani S, Mantovani A, et al. „Differential effect of benzydamine on pro-versus anti-inflammatory cytokine production: lack of inhibiti on of in terleuki n-lo and interleukin-1 receptor antagonist“. Int) din Lab Res. 2000; 30(1):17-9
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