Binding of an agent to the 3' cap of telomeric DNA can interfere with the telomerase enzyme and give the appearance of a telomerase inhibitor, providing a novel mechanism of action for anti-cancer therapy with interest to life extension.  Compounds that tend to associate with this target are large aromatic compounds with a polar charge,   and Berberine has been found to bind to this target with a 1:1 stoichiometric ratio with relatively high affinity;  which has preceded Berberine derivatives being synthesized for higher affinity.   Binding specificities for Berberine can be read here. 
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