Steroid muscle weakness

Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.

Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

Corticosteroid side effects may cause weight gain, water retention, flushing (hot flashes), mood swings or insomnia, and elevated blood sugar levels in people with diabetes. Any numbness or mild muscle weakness usually resolves within 8 hours in the affected arm or leg (similar to the facial numbness experienced after dental work). Patients who are being treated for chronic conditions (., heart disease, diabetes, rheumatoid arthritis) or those who cannot temporarily discontinue anti-clotting medications should consult their personal physician for a risk assessment.

Many athletes, ball players, fighters, and any athlete who could benefit from the therapeutic relief often supplement with Deca Durabolin. Such individuals commonly have no desire to build any new lean muscle mass, but the relief alone is invaluable. Further, such relief can be obtained by a very low dose. A slightly higher dose will provide relief, greatly enhance overall recovery, and enhance muscular endurance. When it comes to performance enhancement, most athletes will find this steroid is hard to beat. More importantly, the relief effects of Deca Durabolin are not masking or false; this anabolic steroid shares nothing in common with over the counter painkillers or prescription painkillers like opiates. Such painkillers only mask the pain, whereas Deca Durabolin can actually heal the body.

Steroid muscle weakness

steroid muscle weakness

Many athletes, ball players, fighters, and any athlete who could benefit from the therapeutic relief often supplement with Deca Durabolin. Such individuals commonly have no desire to build any new lean muscle mass, but the relief alone is invaluable. Further, such relief can be obtained by a very low dose. A slightly higher dose will provide relief, greatly enhance overall recovery, and enhance muscular endurance. When it comes to performance enhancement, most athletes will find this steroid is hard to beat. More importantly, the relief effects of Deca Durabolin are not masking or false; this anabolic steroid shares nothing in common with over the counter painkillers or prescription painkillers like opiates. Such painkillers only mask the pain, whereas Deca Durabolin can actually heal the body.

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